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GRB2 ADAPTOR PROTEIN
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DeCS
Descriptor
English
:
GRB2 Adaptor Protein
Descriptor
Spanish
:
Proteína Adaptadora GRB2
Descriptor
Portuguese
:
Proteína Adaptadora GRB2
Synonyms
English
:
Growth Factor Receptor-Bound Protein-2
Tree Number:
D12.644.360.024.297
D12.776.157.057.026
D12.776.476.024.377
Definition
English
:
A signal transducing adaptor protein that links extracellular signals to the
MAP KINASE SIGNALING SYSTEM
. Grb2 associates with activated
EPIDERMAL GROWTH FACTOR
RECEPTOR and
PLATELET-DERIVED GROWTH FACTOR
RECEPTORS via its SH2 DOMAIN. It also binds to and translocates the
SON OF SEVENLESS PROTEINS
through its SH3 DOMAINS to activate PROTO-ONCOGENE PROTEIN P21(RAS).
History Note
English
:
2006(1992)
Allowable Qualifiers
English
:
administration & dosage
adverse effects
agonists
antagonists & inhibitors
analysis
biosynthesis
blood
cerebrospinal fluid
chemistry
classification
chemical synthesis
contraindications
drug effects
deficiency
diagnostic use
economics
genetics
history
immunology
isolation & purification
metabolism
pharmacology
physiology
pharmacokinetics
poisoning
radiation effects
supply & distribution
secretion
standards
toxicity
therapeutic use
ultrastructure
urine
Record Number:
50766
Unique Identifier:
D051380
Occurrence in VHL
:
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